2月11日，由於.Net framework 4、4.5、4.5.1已經停止支持（https://blogs.msdn.microsoft.com/dotnet/2015/12/09/support-ending-for-the-net-framework-4-4-5-and-4-5-1/），
有人提到是否可以爲Exchange Server安裝最新的.Net Framework 4.6.1，產品組的迴應如下：
We wanted to post a quick note to call out that since yesterday, the .NET Framework 4.6.1 has been made a recommended update on WU (Windows Update).
As we have already stated in the Exchange Supportability Matrix, at this time, this version of .NET framework is not supported by Exchange. In fact, we know of some issues if it is installed.
We are working with the .NET team to ensure that Exchange customers have a smooth transition to .NET Framework 4.6.1, but in the meantime, delay this particular .NET update on your Exchange servers (information on how this can be accomplished can be found in the KB article 3133990, How to temporarily block the installation of the .NET Framework 4.6.1).
總的來講就是產品組尚未驗證完兩個產品的兼容性，不確定是否還會存在潛在的issues，提醒廣大管理員在使用WSUS或者windows update給Exchange Server打補丁的時候注意一下這個。
另：參考Exchange Server的兼容性矩陣：https://technet.microsoft.com/zh-cn/library/ff728623(v=exchg.150).aspx
另2：Exchange 2010與.Net Framework4.0的老問題：https://social.technet.microsoft.com/Forums/en-US/521a346d-48c3-4231-a274-b14d1176ec9e/owa-broke-after-installing-net-framework-40?forum=exchange2010